Thread: T=remote_smtp defer (-53): retry time not reached for any host

You can solve this issue on cPanel servers as follows :

/usr/sbin/exim_tidydb -t 1d /var/spool/exim retry > /dev/null
/usr/sbin/exim_tidydb -t 1d /var/spool/exim reject > /dev/null
/usr/sbin/exim_tidydb -t 1d /var/spool/exim wait-remote_smtp > /dev/null

/scripts/courierup — force
/scripts/eximup –force